Author/Authors :
Salehi Sourmaghi, M.H. tehran university of medical sciences tums - Faculty of Pharmacy and Research Center of Medicinal Plants - Department of Pharmacognosy, تهران, ايران , Azadi, B. tehran university of medical sciences tums - Faculty of Pharmacy and Research Center of Medicinal Plants - Department of Pharmacognosy, تهران, ايران , Amin, Gh. tehran university of medical sciences tums - Faculty of Pharmacy and Research Center of Medicinal Plants - Department of Pharmacognosy, تهران, ايران , Amini, M. tehran university of medical sciences tums - Faculty of Pharmacy and Research Center of Medicinal Plants - Department of Medicinal Chemistry, تهران, ايران , Sharifzadeh, M. tehran university of medical sciences tums - Faculty of Pharmacy and Research Center of Medicinal Plants - Department of Toxicology and Pharmacology, تهران, ايران
Abstract :
Background and the purpose of study: Galanthus transcaucasicus Fomin (Amaryllidaceae) is an endemic species to the Caucasia and Alborz mountains in Iran which locally named “Gol-e-Barfi”. While there are many reports on pharmacological activities of Galanthus species’ alkaloids, there is no report on G. transcaucasicus and this article is the first phytochemical study on this species.Methods: Extracted alkaloids from G. transcaucasicus bulbs were isolated using different chromatographic methods and the structures of the components were determined by physical and spectroscopic data. Results: Five isoquinoline type alkaloids namely galanthamine(8.04%), narwedine(6.90%), lycorine(19.48%), caranine(3.45%) and tazettine(5.75%) of total alkaloid extract were isolated from the bulbs of Galanthus transcaucasicus Fomin. Major conclusion: Because of the presence of biologically active alkaloids especially galanthamine and the major alkaloid lycorine in Gol-e-Barfi, the plant may be used as a natural source for pharmaceutical purposes.
Keywords :
Galanthus transcaucasicus , Galanthamine , Lycorine , Tazettine , Isoquinoline alkaloids
