Author/Authors :
Hosseini, Saeed tehran university of medical sciences tums - Endocrinology and Metabolism Clinical Sciences Institute, Endocrinology and Metabolism Research Center, تهران, ايران , Fallah Huseini, Hasan ACECR - Plants Research Center, Medicinal Plants Research Center - 2Pharmacology and Applied Medicine Department, ايران , Larijani, Bagher tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, تهران, ايران , Mohammad, Kazem tehran university of medical sciences tums - School of Public Health - Department of Epidemiology and Biostatistics, تهران, ايران , Najmizadeh, Alireza Karaj Diabetes Society, ايران , Nourijelyani, Keramt tehran university of medical sciences tums - School of Public Health - Department of Epidemiology and Biostatistics, تهران, ايران , Jamshidi, Leila tehran university of medical sciences tums - School of Public Health - Department of Nutrition, تهران, ايران
Abstract :
Background: Juglans regia L. (J. regia ) is one of the medicinal plants traditionally used for treatment of diabetes in Iranian medicine. The effect of this plant has already been investigated on animal models; however, this is the first study conducted on human subjects. The aim of this study is to investigate the hypoglycemic effect of J. regia leaves aqueous extract in type 2 diabetes patients. Fifty eight Iranian male and female patients with type 2 diabetes were enrolled. The patients were randomly allocated into two groups. One group (n = 30) received J. regia leaves extract while the other group (n = 28) received placebo. Fasting blood samples were collected at the beginning of the study and after two months for determination of HbA1c and blood glucose level as a main outcome and insulin, SGOT, SGPT, and ALP level as secondary outcome. Results: Our analysis showed that serum fasting HbA1C and blood glucose levels were significantly decreased and the insulin level was increased in patients in the J. regia arm. Conclusions: The results indicate that J. regia aqueous extract favorably affects blood levels of glucose, insulin and HbA1C in type 2 diabetic patients.
Keywords :
J. regia , Insulin , Diabetes mellitus , Glucose , Liver enzymes
