Title of article :
Determination of diosmin in pharmaceutical formulations using Fourier transform infrared spectrophotometry
Author/Authors :
Bunaciu, Andrei A. Cromatec_plus srl - Analytical Research Department, Romania , Udristioiu, Gabriela Elena University of Bucharest - Faculty of Chemistry - Department of Organic Chemistry, Romania , Ruta, Lavinia L. University of Bucharest - Faculty of Chemistry - Department of Organic Chemistry, Romania , Fleschin, Serban University of Bucharest - Faculty of Chemistry - Department of Organic Chemistry, Romania , Aboul-Enein, Hassan Y. National Research Centre - Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, Egypt
Abstract :
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of diosmin in different pharmaceutical drugs. Conventional KBr-spectra were compared for best determination of active substance in commercial preparations. The Beer– Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.
Keywords :
FT , IR analysis , Diosmin , Chemometric methods , Drug analysis
Journal title :
Saudi Pharmaceutical Journal(SPJ)
Journal title :
Saudi Pharmaceutical Journal(SPJ)
