Title of article
Cardiovascular effects of two amides (Piperine and Piperdardine) isolated from Piper tuberculatum Jacq.
Author/Authors
Araújo-Júnior, João X. de Federal University of Alagoas - Institute of Chemistry and Biotechnology, School of Nursing and Pharmacy - Laboratory of Cardiovascular Pharmacology, Brazil , Ribeiro, Êurica Adélia N. Federal University of Alagoas - School of Nursing and Pharmacy - Laboratory of Cardiovascular Pharmacology, Brazil , Silva, Sâmia Andrícia S. da Federal University of AlagoasSchool of Nursing and Pharmacy - Laboratory of Cardiovascular Pharmacology, Brazil , Costa, Cintia Danieli F. da Federal University of AlagoasSchool of Nursing and Pharmacy - Laboratory of Cardiovascular Pharmacology, Brazil , Alexandre-Moreira, Magna Suzana Federal University of Alagoas - Institute of Biological Sciences and Health - Laboratory of Pharmacology and Immunity, Brazil , Santos, Bárbara V. O. Federal University of Paraíba - Laboratory of Pharmaceutical Technology, Brazil , Chaves, Maria Célia de O. Federal University of Paraíba - Laboratory of Pharmaceutical Technology, Brazil , Medeiros, Isac A. de Federal University of Paraíba - Laboratory of Pharmaceutical Technology, Brazil
From page
265
To page
274
Abstract
Cardiovascular activity of the fraction from the plant Piper tuberculatum, containing two amides, piperine and piperdardine (PTPP) was evaluated in this work. Intravenous injection of PTPP (1.5; 2.5 and 5.0 mg/kg, i.v.) in normotensive rats reduced the diastolic blood pressure (DBP) and heart hate (HR) in a dose dependent manner. This effect was affected in rats treated with methysergide (5 mg/Kg, i.v), an inespecific serotonergic antagonist. In anesthetized and ventilated animals, PTPP lowered the DBP and the HR in a significative manner. However these effects were completely abolished after bilateral cervical vagotomy. The PTPP relaxed phenylephrine or KCl 80 mM pre-contracted rat aortic artery rings both with intact or denuded endothelium. This response was independent of the presence of a functional vascular endothelium. These results taken together, suggest that the hypotension and bradicardia observed after PTPP is probably due to direct cardiac activation and as a result of a direct spasmolytic effect.
Keywords
Cardiovascular activity , piperdardine , piperine , wistar rats
Journal title
Emirates Journal of Food and Agriculture
Journal title
Emirates Journal of Food and Agriculture
Record number
2554303
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