Author/Authors :
Mejia-Barajas, Jorge A. Cuidad Universitaria, Mexico , Mejia-Barajas, Jorge A. University Michoacana of San Nicolas de Hidalgo - Instituto de Investigaciones Quimico Biologicas, Mexico , Rio, Rosa E. N. Del Cuidad Universitaria, Mexico , Rio, Rosa E. N. Del University Michoacana of San Nicolas de Hidalgo - Instituto de Investigaciones Quimico Biologicas, Mexico , Flores-Garcia, Alberto Cuidad Universitaria, Mexico , Flores-Garcia, Alberto University Michoacana of San Nicolas de Hidalgo - Instituto de Investigaciones Quimico Biologicas, Mexico , Martinez-Pacheco, Mauro M. Cuidad Universitaria, Mexico , Martinez-Pacheco, Mauro M. University Michoacana of San Nicolas de Hidalgo - Instituto de Investigaciones Quimico Biologicas, Mexico
Abstract :
Tagetes lucida (common name Santamaria) is a native herb widely used in the area with an important economic potential. It has several uses, such as, food, antiseptic, to control diseases infectious and spirituals. The objective of this work was to determine the agent of the cytotoxic activity from T. lucida. 17 straw extracts from different organs of T. lucida were obtained by cold maceration (methanol:chloroform), successive maceration (hexane, dichloromethane and methanol), infusion and extraction Soxhlet (ethyl acetate). The mostly of the plant extract were citotoxic to the crustacean A. salina. Hexanic extracts were notable for their cytotoxic effect. They were purified the 7-methoxycoumarin and 6,7-dimethoxycoumarin from leaf hexanic extract and both compounds caused citotoxicity in A. salina, with LC50 values of 28 and 238 μg/ml, respectively. We find that the cytotoxic effect observed in T. lucida is due to the coumarins.
