Profil Darah dan Urin Tikus Teraruh Hipertensi yang diberi SuplemenPuri Jambu Batu Merah (Psidium guajava)(Blood and Urine Profiles of Spontaneous Hypertensive Rats Supplementedwith Pink Guava (Psidium guajava) Puree)

profiles of Spontaneous Hypertensive Rats (SHR). Twenty-four male SHR rats were divided into four groups (control, CG (distilled water); low dosage group, LDG (0.5 g/kg body weight); medium dosage group, MDG (1.0 g/kg body weight); and high dosage group, HDG (2.0g/kg body weight)). The rats were given pink guava puree via force-feeding and fed ad libitum for 28 days in individual cages. Organ weights and serum lipid profiles were not significantly different between the groups. Blood glucose value (mmol/l) for MDG (5.53±0.69) was significantly higher than CG (4.53±0.39) and LDG(4.80±0.54). Blood chemistry analysis showed no significant difference in total antioxidant status, urea, alkaline phosphate and globulin between the groups. There were significant differences in the blood hematology, concentrations total bilirubin, gamma-glutamyl transpeptidase (GGT), total protein, albumin and albumin:globulin ratio between CG and treated groups. LDG’s red blood cell (10.95±0.57 ×1012/l) and platelet (941.17±139.0 ×109/l) were higher compared to CG (10.05±0.63×1012/l; 858.83±163.4 ×109/l) respectively. LDG (3.51 umol/l) had lower total bilirubin concentration than CG (4.25 umol/l). GGT level was significantly higher in HDG (8.67 U/l) compared to CG and MDG (7.00 U/l). Albumin:globulin ratio values were significantly lower in CG (1.50) than MDG (1.36) and HDG (1.37). In conclusion, this study shows pink guava (Psidium guajava) puree supplementation did not have significant effects on serum lipid and urine profiles, organ weight and blood glucose concentration of SHR.