Author/Authors :
Parejiya, Punit B. K. B. Institute of Pharmaceutical Education and Research, India , Shelat, Pragna K. K. B. Institute of Pharmaceutical Education and Research, India , Patel, Rakshit C. K. B. Institute of Pharmaceutical Education and Research, India , Barot, Bhavesh S. K. B. Institute of Pharmaceutical Education and Research, India , Shukla, Arun K. K. B. Institute of Pharmaceutical Education and Research, India
Abstract :
Milnacipran is an antidepressant drug belonging to the class of serotonin and noradrenaline reuptake inhibitors. A new, rapid, simple and sensitive spectrophotometric method has been developed for the determination of milnacipran in bulk and pharmaceutical formulations. The linearity was observed in the concentration range of 2-45 μg mL^-1. The method is based on spectrophotometric determinaiton. Absorbance of milnacipran was determined at 220 nm wavelength. The method was validated in terms of accuracy and precision (intra and interday variations). This method is extended to pharmaceutical preparations. Results of the analysis were validated statistically and by recovery studies. The proposed method was found accurate, reproducible and economical for the routine analysis of milnacipran in bulk and pharmaceutical formulation.
