Author/Authors :
NASIR, NADIAH MAD Universiti Putra Malaysia - Department of Chemistry, Malaysia , RAHMANI, MAWARDI Universiti Putra Malaysia - Department of Chemistry, Malaysia , SHAARI, KHOZIRAH Universiti Putra Malaysia - Department of Chemistry, Malaysia , KASSIM, NUR KARTINEE Universiti Putra Malaysia - Department of Chemistry, Malaysia , GO, RUSEA Universiti Putra Malaysia - Department of Biology, Malaysia , STANSLAS, JOHNSON Universiti Putra Malaysia - Department of Medicine, Malaysia , JEYARAJ, ETHEL JEYASEELA Universiti Putra Malaysia - Department of Medicine, Malaysia
Abstract :
Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00 μΜ.
Keywords :
Calophyllum gracilipes , gracixanthone , sterols , trapezifolixanthone , zeyloxanthanone
