Author/Authors :
MOHAMED ISMAIL, NOR AZLIN Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Obstetrics Gynaecology, Malaysia , MOHD ARIS, NORKHATIJAH Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Obstetrics Gynaecology, Malaysia , ABDULLAH MAHDY, ZALEHA Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Obstetrics Gynaecology, Malaysia , AHMAD, SHUHAILA Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Obstetrics Gynaecology, Malaysia , MOHD NAIM, NORZILAWATI Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Obstetrics Gynaecology, Malaysia , SIRAJ, HARLINA HARLIZAH Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Obstetrics Gynaecology, Malaysia , JAAFAR, ROHANA Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Paediatrics, Malaysia , ISHAK, SHAREENA Universiti Kebangsaan Malaysia - Faculty of Medicine - Department of Paediatrics, Malaysia , HARUN, ROSLAN Universiti Kebangsaan Malaysia - Faculty of Medicine, Medical Molecular Biology Institute, Malaysia , ABD JAMAL, ABD RAHMAN Universiti Kebangsaan Malaysia - Faculty of Medicine, Medical Molecular Biology Institute, Malaysia , WAN NGAH, WAN ZURINAH Universiti Kebangsaan Malaysia - Faculty of Medicine, Medical Molecular Biology Institute, Malaysia , SYED ZAKARIA, SYED ZULKIFLI Universiti Kebangsaan Malaysia - Faculty of Medicine, Medical Molecular Biology Institute, Malaysia
Abstract :
Gestational Diabetes Mellitus (GDM) is associated with pregnancy complications, however its mechanism has not been fully understood. The aim of this study was to investigate the single nucleotide polymorphism (SNP) for identifying candidate genes involve in risk factors and complications of GDM. A total of 174 pregnant women with GDM and 114 healthy pregnant women were genotyped with 384 SNPs from 236 genes. The SNPs identified were rs10946398 (CDKAL1) in GDM risk factors; rs328 (LPL) and rs1042778 (OXTR) in complications of caesarean section; rs5404 (SLC2A2), rs5400 (SLC2A2) and rs13306465 (IRS1) for neonatal intensive care admission. Whereby SNPs rs12255372, rs7901695 and rs7903146 from TCF7L2 gene had six times higher risk (OR, 6.40-6.53) for T2DM at postpartum. In conclusion, although the above SNPs were identified with GDM risk factors and complications among pregnant Malaysian women with GDM, a larger study is needed to ascertain this candidate genes actual association.
Keywords :
Complications , gestational diabetes mellitus , single nucleotide polymorphisms , risks , Malaysia
