Author/Authors :
heidari-keshel, s. shahid beheshti university of medical sciences, تهران, ايران , entezari, m. department of chemistry, islamic azad university, shahre-qods branch, ايران , rezaei-tavirani, m. shahid beheshti university of medical sciences, تهران, ايران , ebrahimi, m. shahid beheshti university of medical sciences, تهران, ايران , rezaei-tavirani, m. ilam university of medical sciences, ايران
Abstract :
Aim: In this study, we tried to prepare a nano compound with a new way in functionalization as an anti-gastric cancer candidate. Background: Functionalization of nano-tubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that is made of isatin, which urea can be useful in cancer studies. Patients and methods: This compound with one-step reaction functionalized MWNT-COOH, which is a new class in modification. This product has been investigated by FT-IR, Raman and SEM. Anti-cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed. Results: The two bands around 2800-2900cm-1, which are seen in functionalized products are attributed to the CH stretching of MWNT-COOH defects. Conclusion: Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy. © 2013 RIGLD.
Keywords :
Anti , cancer , Functionalization , Mtt , One , pot reaction
