Author/Authors :
Khorramdelazad, Hossein rafsanjan university of medical sciences - Molecular Medicine Research Center, ايران , Hassanshahi, Gholamhossein rafsanjan university of medical sciences - Molecular Medicine Research Center, ايران , Nasiri Ahmadabadi, Behzad rafsanjan university of medical sciences - Immunology of Infectious Diseases Research Center, ايران , Kazemi Arababadi, Mohammad rafsanjan university of medical sciences - Immunology of Infectious Diseases Research Center, ايران
Abstract :
Background: The transforming growth factor-β (TGF-β) is an important cytokine with anti-inflammatory properties. Objectives: The main purpose of this study was to compare the serum levels of TGF-β in a group of chronic HBV infected (CHB) patients as well as healthy individuals from South-East of Iran. Patients and Methods: Sixty patients with CHB as well as sixty healthy individuals were enrolled in the study. ELISA technique was applied to measure the serum levels of TGF-β in both groups. Results: Our results revealed that the serum levels of TGF-β were significantly increased in CHB patients in compare to healthy controls. Conclusions: According to this result, it may be concluded that high serum levels of TGF-β may be a mechanism by which immune response against HBV is suppressed.
