Author/Authors :
Montella, Maurizio Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - Epidemiology Unit, Italy , Malvezzi, Matteo Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - “Mario Negri” Farmachological Research Institute - Department of Epidemiology, Italy , Malvezzi, Matteo Università degli Studi di Milan - Department of Clinical Sciences and Community Health, Italy , Grimaldi, Maria Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - Epidemiology Unit, Italy , Nocerino, Flavia Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - Epidemiology Unit, Italy , Frigeri, Ferdinando Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - Hematology Unit, Italy , Pinto, Antonio Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - Hematology Unit, Italy , Giudice, Aldo Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - Epidemiology Unit, Italy , Crispo, Anna Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - Epidemiology Unit, Italy
Abstract :
Background: In many regions of southern Italy, hepatitis C virus (HCV) infection represents a major health problem (with a prevalence rate between 6% and 13%). HCV is associated with different kinds of neoplasms such as non-Hodgkin lymphomas (NHL), and with autoimmune diseases (cryoglobulinemia), which develop after the virus has caused immune system alterations. Objectives: To provide updated information on trends in mortality in a major metropolitan area of southern Italy from NHL, multiple myeloma and Hodgkin disease we analyzed cancer mortality data from 1988 to 2009. Materials and Methods: Mortality data were extracted from National death certificates by age groups, gender, residence and cause of death by the Italian national institute of statistics (ISTAT). Age-standardized mortality rates (SMR) were computed applying the direct method and using the world standard population. To quantify the recent direction of temporal trends in older populations over time, truncated age-adjusted mortality rates were calculated for people aged 65 years and older. Cancer mortality trends were described using their estimated annual percent change (EAPC) and related 95% Confidence Interval (CI). Results: Statistically significant increasing EAPC was found among women for NHL (+2.0% / year), while statistically significant decrease was found among men and women for HD (-3.5% / year, -3.4% / year, respectively). No statistically significant EAPC was found for multiple myeloma. Conclusions: The association between viral hepatitis and NHL in the area of interest might provide some degree of explanation to this finding. Our data confirm that due to epidemic infection of HCV in the area of Naples, a high mortality for NHL persists, moreover the adoption of standard therapeutic protocols administered in full accordance with an evidence-based approach and current guidelines explain reduced mortality from Hodgkin lymphomas
Keywords :
Hepacivirus , Lymphoma, Non , Hodgkin , Mortality , Analysis
