Title of article :
The Effect of Helicobacter pylori Eradication on Liver Fat Content in Subjects With Non-Alcoholic Fatty Liver Disease: A Randomized Open-Label Clinical Trial
Author/Authors :
Jamali, Raika tehran university of medical sciences tums - Student Scientific Research Center, تهران, ايران , Mofid, Alireza tehran university of medical sciences tums - Sina Hospital - Internal Medicine Ward, تهران, ايران , Vahedi, Homayoon tehran university of medical sciences tums - Digestive Diseases Research Institute, تهران, ايران , Farzaneh, Rojin tehran university of medical sciences tums - Sina Hospital - Internal Medicine Ward, تهران, ايران , Dowlatshahi, Shahab tehran university of medical sciences tums - Sina Hospital - Internal Medicine Ward, تهران, ايران
Abstract :
Background: The role of Helicobacter pylori (HP) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is unclear.Objectives: The aim of this study was to evaluate the effect of HP eradication on liver fat content (LFC), liver function tests (LFT), lipid profile, and homeostasis model assessment-IR (HOMA-IR) index in NAFLD.Patients and Methods: Dyspeptic patients with increased serum aminotransferase levels were enrolled in the study. The exclusion criteria were factors affecting serum aminotransferase or HP treatment strategy. Participants with persistent elevated serum aminotransferase level and ultrasound criteria for identification of fatty liver were presumed to have NAFLD. “NAFLD liver fat score” was used to classify NAFLD. Those with “NAFLD liver fat score” greater than -0.64 and positive results for urea breath test (UBT), were included. Lifestyle modification was provided to all participants. HP eradication was performed in intervention arm. LFC, fasting serum glucose (FSG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), cholesterol (CHOL), high and low-density lipoprotein (HDL, LDL), and HOMA-IR were checked at baseline and after that, at intervals of eight weeks and twenty four weeks.Results: One hundred (49 males) patients with the mean age of 43.46 (± 11.52) were studied. Repeated measure ANOVA showed a significant reduction in LFC, anthropometric measurements, and laboratory parameters (except for HDL) in the both groups during the study; however, no significant difference was observed between the groups.Conclusions: It seems that HP eradication per se might not affect LFC, LFT, lipid profile, and insulin resistance in dyspeptic NAFLD patients.
Keywords :
Non , alcoholic Fatty Liver Disease , Helicobacter Pylori , Insulin Resistance , Alanine Transaminase , Aspartate AminotransferasesImplication for health policy , practice , research , medical education:Since Helicobacter pylori (HP) treatment is not difficult in most cases, discovering its role in diseases apart from the stomach could be of great importance for public health. This study evaluated the short , term effect of HP eradication in nonalcoholic fatty liver disease.Copyright © 2013, Kowsar Corp. , Published by Kowsar Corp. This is an open , access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.1. BackgroundThe effect of gut microbiota on the development and progression of liver cell damage has recently come to interest. In this regard, helicobacter pylori (HP) deoxy , ribo , nucleic acid (DNA) was detected in patients with various etiologies of chronic liver disease (CLD) including nonalcoholic fatty liver disease (NAFLD) (1 , 4). Regardless of HP DNA existence in liver samples, no bacteria could be cultured (5).There are proposed mechanisms for the development of NAFLD in patients with HP infection. Taylor et al. expressed the earlier theory that HP species would produce a liver specific toxin that causes liver cell damage (6). Afterwards, it was developed that HP invasion to intestinal mucosa might increase gut permeability and facilitate the bacterial endotoxin passage via portal vein to the liver (7). Since HP treatment is not difficult and comparatively not expensive in most cases, discovering its role in diseases apart from the stomach could be of great importance for public health.Despite accumulated evidence on the importance of HP on NAFLD pathogenesis , currently the way in which HP eradication would affect clinical as well as paraclinical state of patients with NAFLD is not well cleared (8 , 11).2. ObjectivesThis study was designed to determine the short term effects of HP eradication on liver fat content, liver function tests (LFT), and metabolic profile (biochemical parameters and anthropometric measurements) in a sample of dyspeptic NAFLD patients. Considering that HP eradication in all
Journal title :
Hepatitis Monthly
Journal title :
Hepatitis Monthly
