Author/Authors :
Khoshnood, Asghar yazd shahid sadoghi university of medical sciences - Shahid Sadoughi Hospital - Department of Internal Medicine, ايران , Nasiri Toosi, Mohsen tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Gastroenterology, تهران, ايران , Faravash, Mohammad Jafar tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Gastroenterology, تهران, ايران , Esteghamati, Alireza tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Endocrinology, تهران, ايران , Froutan, Hosein tehran university of medical sciences tums - Imam Khomini Hospital - Department of Gastroenterology, تهران, ايران , Ghofrani, Hadi tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Gastroentrology, تهران, ايران , Kalani, Mohammad tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Gastroentrology, تهران, ايران , Miroliaee, Arash tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Gastroentrology, تهران, ايران , Abdollahi, Ahmad tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Pathology, تهران, ايران , Yasir, Andrabi tehran university of medical sciences tums - Imam Khomeini Hospital - Department of Gastroenterology, تهران, ايران
Abstract :
Background: Insulin-like growth factor is a polypeptide with endocrine, autocrine and paracrine effects which its structure is similar to the insulin molecule. While various tissues secrete IGF-1, 90% of the circulating IGF-1 is secreted by liver. Cirrhosis of liver is a condition accompanied by decreased level of IGF-1, in which the level of IGF-1 may be further decreased thorough the progression of the disease. Objectives: The aim of the present study was to demonstrate the relation between the IGF-1 levels and severity of liver disease according to Child- Pugh and Model for end stage liver diseases (MELD) Scores. Patients and Method: This was a descriptive-analytic cross sectional study performed on patients with cirrhosis admitted to gastroenterology clinic of Imam Khomeini Hospital in Tehran, Iran during the years 2007-2008. The diagnosis was based on liver biopsy. Initially for all patients, laboratory investigations including IGF-1, CBC, liver Enzymes, Alkaline phosphates, serum Albumin, Creatinine, direct and total Bilirubin were conducted. Also ultrasound and endoscopy were performed for evaluation of ascites and varices. Results: 100 patients with cirrhosis with a male to Female ratio of 63:37 and a mean age of 44.4 ± 15 years were enrolled in the study. Median IGF-1 was 92.95 ± 91.51 ng/mL. 14 patients (14%) had IGF-1 within normal limits while 86 patients (86%) had abnormal IGF-1 levels. In all patients the correlation coefficient between IGF-1 and MELD was -0.317 (P = 0.001) and 0.478 between IGF-1 and Child- Pugh (P 0.001). Conclusions: Our findings showed that IGF-1 can be used as an index for evaluating the severity of cirrhosis; also it can be used for determining the severity of the disease, when liver biopsy is not possible.
Keywords :
Insulin , Like Growth Factor I , Liver Cirrhosis , Child
