Author/Authors :
Zhang, Haiying Qingdao University - Medical College, The Second Affiliated Hospital - Department of Gastroenterology, China , Zhang, Haiying Qingdao Central Hospital - Department of Gastroenterology, China , Chen, Lizhen Qingdao University - Medical College, China , Xin, Yongning Qingdao Municipal Hospital - Department of Gastroenterology, China , Lou, Yuangui Qingdao University - Medical College, The Second Affiliated Hospital - Department of Gastroenterology, China , Lou, Yuangui Qingdao Central Hospital - Department of Gastroenterology, China , Liu, Yang Qingdao University - Medical College, China , Xuan, Shiying Qingdao Municipal Hospital - Department of Gastroenterology, China
Abstract :
Context: Our objective was to evaluate the effect of gene polymorphisms of apolipoprotein C3 (APOC3) on the development of non-alcoholic fatty liver disease (NAFLD) in different populations.Evidence Acquisition: We performed a meta-analysis of all relevant studies published in the literature. A total of 115 clinical trials or reports were identified, but only seven trials met our inclusion criteria. A meta-analysis was performed according to the Cochrane Reviewers’ Handbook recommendations. Results: Five hospital-based and two population-based case-control studies were included in the final analysis. The overall frequency of APOC3 gene polymorphisms was 67.5% (1177/1745) in NAFLD and 68.8% (988/1437) in controls. The summary odds ratio for the association of gene polymorphisms of APOC3 and the risk of NAFLD was 1.03 (95% CI: 0.89-1.22),which was not statistically significant (P 0.05). Conclusions: Our meta-analysis, while not ruling out possible publication bias, showed no association between gene polymorphisms of APOC3 and the risk of NAFLD development in different populations in the world.
