Author/Authors :
SAFRI, NURUL HUDA MOHAMED International Islamic University Malaysia - Kulliyah of Engineering - Department of Biotechnology Engineering, Bioprocess and Molecular Engineering Research Unit, Malaysia , Mel, Maizirwan International Islamic University Malaysia - Faculty of Engineering - Department of Biotechnology Engineering, Bioprocess Engineering Research Unit, Malaysia , FOO, DOMINIC C.Y. University of Nottingham Malaysia - Department of Chemical and Environmental Engineering, Malaysia , NG, DENNY K.S. University of Nottingham Malaysia - Department of Chemical and Environmental Engineering, Malaysia , CHEW, IRENE M.L. Monash University Sunway Campus - School of Engineering, Malaysia
Abstract :
The main objective of this research work was to model and optimise the production of a locally-developed Infectious Coryza (IC) vaccine. The simulation work was performed using a commercially available batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost to benefit ratio (CBR) when the annual production was set to increase by 100%. Based on the economic analysis, the selected debottlenecking scheme has an annual predicted revenue of USD 240 million, with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition, the payback period of the selected scheme is estimated to be within three years.
Keywords :
process simulation , modelling , debottlenecking , optimisation
