Title of article :
The Teratogenic Mechanism of Echinochrome as a Hypoglycemic Agent on Wistar Rats
Author/Authors :
Mohamed, Ayman S Department of Physiology Zoology - Faculty of Science - Cairo University, Egypt , Salah EL Din, Eman Y Department Comparative Anatomy and Embryology Zoology - Faculty of Science - Cairo University, Egypt , Farag, Neveen A Department Comparative Anatomy and Embryology Zoology - Faculty of Science - Cairo University, Egypt , Tawfik, Abdel Rahman A. Department Comparative Anatomy and Embryology Zoology - Faculty of Science - Cairo University, Egypt
Abstract :
Background:
Echinochrome (Ech) is the active ingredient in the Histochrome drug, which possesses strong antioxidant, hypolipidemic and hypoglycemic activity.
Objective:
The present work aimed to characterize the malformations induced by moderate and high dose of Ech during pregnancy.
Methods:
In this study, eighteen (18) female pregnant rats were assigned into 3 groups (6 rats/ group); control group, low dose Ech (0.1 mg/kg) and high dose Ech (1 mg/kg).
Results:
The high dose of Ech caused a significant decrease in the number of embryos, uteri weight, body weight gain, placenta weight, and embryo weight and length. Also, the high dose led to a significant increase in serum AST, ALT, ALP, urea and uric acid of mothers.
Conclusion:
Our findings revealed the first teratogenic effects of high dose Ech. The teratogenic mechanism of Ech works through induction of the hypoglycemic condition in pregnant rats.
Keywords :
Histchrome , Echinochrome , Teratogenicity , Hypoglycemia , Birth defect , Hypolipidemic
Journal title :
Open Biomarkers Journal
