Synthesize of Folic acid Functionalized Dendritic Fibrous Nanosilica and its Application as an Efficient Nanocatalyst for Access to direct Amidation of Carboxylic Acids with Amines

A new nanomaterial based on folic acid functionalized dendritic fibrous nano-silica (FA-KCC-1-NH2) was synthesized and used as a recyclable solid acid and heterogeneous nanocatalyst towards efficient amidation of a variety of carboxylic acids with amines in toluene under reflux conditions. KCC-1 porous nanomaterials were produced utilizing a hydrothermal technique and next functionalized with folic acid moieties to yield KCC- 1-NH-FA nanocatalyst. The morphology, surface charge and size of KCC-1, KCC-1-NH2 and KCC-1-NH-FA nanoparticles were verified by field emission scanning electron microscope (FESEM), dynamic light scattering (DLS), zeta potential and transmission electron microscopy (TEM), respectively. The pore size of KCC-1-NH-FA nanoparticles were moreover investigated with Brunauer-Emmett Teller (BET) where results revealed that the surface of this nanocomposite was expanded. The synthesized KCC-1-NH-FA nanoparticles showed effective catalytic activity in amidation of carboxylic acids with amines affording in high yields (76-89%) in short period of times. Moreover, other advantages of present method are easy workupcondition and recyclability of catalyst which gives economic rewards.