Antihyperglycemic activity of functional drinks based on Java Tea (Orthosiphon aristatus) in streptozotocin induced diabetic mice

Diabetes is a group of diseases marked by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. Diabetes can lead to serious complications and premature death. Antioxidant compounds in functional drinks such as flavonoid may offer some protection against the early stage of diabetic mellitus and the development of complications. The objective of this study was to investigate the antihyperglycemic effects of functional drinks formulations containing different varieties of Java Tea on streptozotocin induced diabetic mice. The results indicated that the administration of functional drinks in diabetic mice restrain the increase of blood glucose and further inhibit the rate of pancreatic beta cells damage. HPLC analysis shows that the bioactive compounds in the extract ingredient are sinensetin, 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, curcumin, desmethoxycurcumin, brazilin, hesperidin and naringin. Consequently, functional drinks based on Java Tea is considered to be a promising functional drink for preventing and treating diabetes.