Author/Authors :
Mishra, Abhinav P. Department of Pharmacy - Pranveer Singh Institute of Technology - Kanpur-Agra-Delhi National Highway (NH-2), Bhauti, Kanpur, Uttar Pradesh, India , Chandra, Suresh Department of Pharmacy - Pranveer Singh Institute of Technology - Kanpur-Agra-Delhi National Highway (NH-2), Bhauti, Kanpur, Uttar Pradesh, India , Tiwari, Ruchi Department of Pharmacy - Pranveer Singh Institute of Technology - Kanpur-Agra-Delhi National Highway (NH-2), Bhauti, Kanpur, Uttar Pradesh, India , Srivastava, Ashish Department of Pharmacy - Pranveer Singh Institute of Technology - Kanpur-Agra-Delhi National Highway (NH-2), Bhauti, Kanpur, Uttar Pradesh, India , Tiwari, Gaurav Department of Pharmacy - Pranveer Singh Institute of Technology - Kanpur-Agra-Delhi National Highway (NH-2), Bhauti, Kanpur, Uttar Pradesh, India
Abstract :
In designing of Prodrugs, targeting can be achieved in two ways: site-specified drug delivery and site-specific drug bioactivation. Prodrugs can be designed to target specific enzymes or carriers by considering enzyme-substrate specificity or carrier-substrate specificity in order to overcome various undesirable drug properties. There are certain techniques which are used for tumor targeting such as Antibody Directed Enzyme Prodrug Therapy [ADEPT] Gene-Directed Enzyme Prodrug Therapy [GDEPT], Virus Directed Enzyme Prodrug Therapy [VDEPT] and Gene Prodrug Activation Therapy [GPAT]. Our review focuses on the Prodrugs used in site-specific drug delivery system specially on tumor targeting.
Keywords :
Prodrug , Xenobiotics , Cytotoxic , ADEPT , GDEPT , GPAT , VDEPT , NTR
