Intra Nasal In situ Gelling System of Lamotrigine Using Ion ActivatedMucoadhesive Polymer

Background:A novel drug delivery system for treating acute epileptic condition. Objective:To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loaded insitu gel, for the treatment of epilepsy to avoidpossible side effects and first pass metabolism associated with conventional treatment. Methods:Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum. Results:All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range. Invitro drug release from themucoadhesive insitu gel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% foroptimized G5 formulation within 20min. Exvivo permeation studies of optimized formulation G5 and control formulation wasestimated. Exvivo permeation studies of G5 insitu formulation done for a period of 12 h resulted in slow, sustained release andgreater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed thatG5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45days in refrigerated condition (4±2ºC). Conclusion:The intranasal insitu gelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which couldenhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug fortreating acute epileptic conditions.