Glucose Tolerance Evaluation in Graves Patients Treated with Methimazole and Radioiodine

The manuscript, “Evaluation of Glucose Tolerance in Methimazole and Radioiodine Treated Graves’ Patients,” by Kiani J et al. (1) compared glucose tolerance in Graves’ disease patients treated with methimazole to those treated with radioiodine. The results indicated that radioiodine therapy had no adverse effects on glucose tolerance or insulin resistance. This study has an impact on whether particular attention should be paid to diabetes mellitus in patients after radioiodine therapy. The conclusion is reasonable, but the design of this study raises several questions concerning glucose tolerance, beyond simply damage to the pancreas caused by radioiodine.