Author/Authors :
Lu, Gang Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Chen, Jie 3rd Hospital Affiliated to Harbin Medical University, China , Guo, Wei Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Qi, Ting Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Zhao, Liping Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Li, Hongmei Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Ji, Yuanyuan Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Wang, Zheng Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Liu, Cuiyun Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Zhao, Shihua Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China , Xiang, Wenhua Chinese Academy of Agricultural Sciences - Harbin Veterinary Research Institute - Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, China
Abstract :
Two equine influenza virus (EIV) strains were isolated during two restricted outbreaks from Heilongjiang Province, China in 2010 and 2011. Phylogenetic analysis of HA1 (hemagglutinin 1) gene revealed that the isolates belonged to Florida 2 sublineage of American lineage. Further analysis of the putative antigenic sites located in HA1 subunit protein revealed each isolate had a unique amino acid change. Analysis of antigenic sites between Chinese EIV and vaccine strains indicated equine influenza (EI) vaccines containing Richmond/1/07-like antigen seemed to have an optimum effect in China. Meanwhile, the Ohio/03 vaccine strain contained in updated ProteqFlu had the most closely genetically relationship with recent EIV isolates in China. China has not its own commercially available EI vaccine and most horses are still unvaccinated. Therefore, to monitor antigenic variation of circulating EIVs and give considerable suggestions on selection of vaccine candidate plays an important role in preventing and controlling EIV in China.
