Author/Authors :
Kim, Sang-Hyeob Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Ji, Ae-Ri Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Park, Jin-Kyu Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Kim, Ah-Young Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Lee, Eun-Mi Kyungpook National University - College of Veterinary Medicine - Department of Pathology, South Korea , Lee, Eun-Joo Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Min, Chang-Woo Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Kang, Kyung-Ku Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Lee, Myeong-Mi Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Sung, Soo-Eun Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Hwang, Meeyul Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Kwak, Dong-Mi Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea , Kim, Tae-Hwan Kyungpook National University - College of Veterinary Medicine - Department of Pathology, South Korea , Jeong, Kyu-Shik Kyungpook National University - College of Veterinary Medicine - Department of Pathology, Korea
Abstract :
Subcutaneous leiomyosarcoma is a malignant tumor that originates from smooth muscles in the skin. Herein, we report a case of subcutaneous leiomyosarcoma that occurred in the ear pinna of a 19-month-old male Smad3+/- mouse. On gross examination, the mass extended to the whole ear auricle and obscured the ear opening. The tumor was approximately 10x10 mm in size, ill-circumscribed, and firm with superficial hemorrhage. The cut surface of the mass was grayish-white and solid with focal necrosis and hemorrhage. Histologically, spindle tumor cells with cigar-like nuclei and plump cells with round nuclei formed broad interlacing fascicles. Additionally, the tumor cells invaded adjacent muscles. Immunohistochemically, the tumor sections had positive reactions for desmine and a-SMA and were partially positive for vimentin while negative for S-100 and myogenin. Based on the results of the examination, we diagnosed this case as subcutaneous leiomyosarcoma.
Keywords :
Ear auricle , Leiomyosarcoma , Smad3+ , , mouse , Subcutaneous
