Author/Authors :
Kayyal, Matin Islamic Azad University, Tehran Medical Branch - Department of Molecular Genetics, ايران , Movafagh, Abolfazl shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Hashemi, Mehrdad Islamic Azad University, Tehran Medical Branch - Department of Molecular Genetics, ايران , Sayad, Arezou shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Emamalizadeh, Babak shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , PourIran, Khashayar shahid beheshti university of medical sciences - School of Medicine - Dept of Medical Genetics, تهران, ايران , Kayyal, Mohammadmoien Islamic Azad University, Tehran Medical Branch - Department of Molecular Genetics, ايران , Eslami Amirabadi, Mohammad Reza Shahid Behashti University of Medical Sciences - Imam Hossein Medical Hospital - Department of Psychiatry, ايران , Zamani, Mahdi tehran university of medical sciences tums - Children’s Medical Center, School of Medicine - Department of Neurology, Department of Medical Genetics, تهران, ايران , Darvish, Hossein shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران
Abstract :
Background Objectives: Attention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs rs11122319, rs11122330 and rs6675281 in the etiology of ADHD in an Iranian children Methods: In this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISC1 gene with ADHD in Iranian population. Two hundred fourthy subjects composed of 120 patients and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs. Results: We found differences in genotype and allele distributions of rs 6675281 polymorphism between our patients and controls. The A, T and A alleles were the more frequent alleles in rs11122319, rs6675281 and rs11122330 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to patients. (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776). Conclusion: Our findings strengthens the role of DISC1 gene as a susceptibility locus for ADHD and indicate that rs6675281 polymorphism is a susceptibility factor for ADHD for the first time in children reported in an Iranian population in this part of the world.
Keywords :
Association , polymorphisms , ADHD , Hyperactivity , DISC1 gene , Iran
