Non-Calculus Signs and Symptoms of Hyperoxaluria andHyperuricosuria in Children: A Single Experience

Background and Aims: Non-calculus presentations of hyperoxaluria (HX) and Hyperuricosuria (HU) are notcommon. The aim of this study was to investigate the relationship of symptomatic non-calculus idiopathic HX,HU and both of them with dysuria, failure to thrive (FTT), recurrent urinary tract infection (UTI), dysmorphic redblood cells (RBCs) and abdominal pain in children.Methods: A cross sectional study was done on 58 children who were aged less than 14 years with historyof persistent microscopic or macroscopic hematuria with HX and/or HU, regardless of having renal calculi,between October 2007 and October 2008. The patients were divided into three groups according to the typeof crystalluria (I, 10 HX; II, 20 HU; and III, 28 HX+HU).Results: The common presenting symptoms were abdominal pain (63%) and dysuria (45%). FTT frequentlyoccurred in female (68%). No significant relation was seen between the groups in terms of gender, macroscopichematuria and recurrent UTI. We found that dysuria, positive family history, FTT, abdominal pain and dysmorphicRBCs in patients with HX were higher when compared to HU group. Moreover, logistic regression analysisshowed the higher odds ratio of FTT, abdominal pain and dysmorphic RBCs in patients with HX+HU groupwhen compared to patients with HU.Conclusions: Although our study showed that non-calculus symptoms and signs of crystalluria such asdysmorphic RBCs, FTT, abdominal pain and dysuria are frequently seen in children with HX, however, furtherstudies are needed.