Effect of Aloe vera gel on lipid profile in alloxan induced diabetic mice

Ethanolic extract of Aloe vera gel was assessed for its hypolipidemic and hypoglycaemic activity. Twenty four mice were divided into four groups. First group act as control and remaining were induced diabetes by administrating alloxan @ 150 mg kg^-1 body weight. Second group served as diabetic control and third group treated with glibenclamide (600μg/kg body weight). Fourth group received ethanolic extract of A. vera gel @ 300 mg kg^-1 body weight for 21 days. The antihyperglycaemic (93.40 mg dL^-1) and hypolipidemic (101.37 mg dL^-1) activity of the gel and was compared with group treated with the standard oral hypoglycaemic agent. Treatment with ethanolic extract of A. vera gel caused the significant change when compared to untreated animals with respect to blood glucose level and lipid profile. The present study clearly indicate a significant reduction in blood glucose level, plasma level, low density lipoprotenis (LDL), cholesterol and increased plasma level of high density lipoproteins (HDL) in alloxan induced diabetes in mice.