Author/Authors :
Meamar, Rokhsareh isfahan university of medical sciences - Isfahan Neurosciences Research Center, ايران , Meamar, Rokhsareh Islamic Azad University, Najafabad Branch - Department of Medical Sciences, ايران , Askari, Gholamreza isfahan university of medical sciences - School of Nutrition and Food Science - Department of Community Nutrition, ايران , Ghasemi, Majid isfahan university of medical sciences - Medical School, Isfahan Neurosciences Research Center - Department of Neurology, ايران , Aghaye Ghazvini, Mohammad Reza tehran university of medical sciences tums - National Institute of Health Research, Isfahan Center of Health Research, تهران, ايران , Vesal, Sahar isfahan university of medical sciences - Isfahan Neurosciences Research Center, ايران , Sharifkhah, Mostafa isfahan university of medical sciences - Isfahan Neurosciences Research Center, ايران , Alaei Faradonbeh, Nazanin Islamic Azad University, Najafabad Branch - Young Researchers Club, ايران , Dehghani, Leila Islamic Azad University, Najafabad Branch - Department of Medical Sciences, ايران
Abstract :
Background: Alzheimer’s disease (AD) is one of the most important neurodegenerative disorder. Anti‑cyclic citrullinated peptide (anti‑CCP) may all be involved in the development of vascular disease such as AD. The aim of this study is detection of seropositivity for anti‑CCP antibody in AD patients. Methods: In our study, 30 patients with AD and 29 healthy controls (age and‑sex matched) were recruited. Homocysteine and anti‑CCP was measured by spectrophotometrically and immunoassay. Results: Mean ± SE anti‑CCP was higher significantly between AD (13.6 ± 3) and healthy subjects (4.8 ± 0.2) (P = 0.006). In the patients, anti‑CCP serum level was in high range (32.1%) of abnormal levels, but there was no significant difference in serum homocysteine in AD patients compared with controls. There is no correlation between anti‑CCP and homocysteine levels in AD patients (P = 0.75), but between age and anti‑CCP level observed a significantly correlation (P = 0.04). Conclusions: It needs more studies to clarify confirmation the role of anti‑CCP antibody production in AD patients.
