Title of article :
FDG-PET/MRI fused data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment
Author/Authors :
Heusner, T.A. University of Dusseldorf - Medical Faculty - Department of Diagnostic and Interventional Radiology, Germany , Mikat, C. University of Duisburg-Essen - Medical Faculty - Department of Diagnostic and Interventional Radiology and Neuroradiology, Germany , Hahn, S. University of Duisburg-Essen - Medical Faculty - Department of Diagnostic and Interventional Radiology and Neuroradiology, Germany , Altenbernd, J. University of Duisburg-Essen - Medical Faculty - Department of Diagnostic and Interventional Radiology and Neuroradiology, Germany , Stahl, A. University of Duisburg- Essen - Medical Faculty - Department of Nuclear Medicine, Germany , Bockisch, A. University of Duisburg- Essen - Medical Faculty - Department of Nuclear Medicine, Germany , Forsting, M. University of Duisburg-Essen - Medical Faculty - Department of Diagnostic and Interventional Radiology and Neuroradiology, Germany , Antoch, G. University of Dusseldorf - Medical Faculty - Department of Diagnostic and Interventional Radiology, Germany
Abstract :
Background: To retrospectively describe imaging characteristics of liver metastases on fused FDG-PET/ MRI data sets and to compare the diagnostic accuracy of MRI and fused FDG-PET/MRI data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment. Materials and Methods: 43 oncological patients (mean age: 56+/- 11 years) were investigated by FDG-PET/CT and liver MRI. FDG-PET data from PET/CT scans were fused with MRI. 556 lesions were evaluated. 5 different evaluation algorithms were used for FDG-PET/ MRI evaluation. The sensitivity, specifity, PPV, NPV and accuracy of MRI and FDG-PET/MRI data for the detection of liver metastases were calculated. A mean follow-up of 647 days served as reference standard. McNemar’s test was used to test for statistically significant differences between MRI and FDG-PET/MRI (p 0.5). Results: The sensitivity, specificity, PPV, NPV and accuracy of MRI for the detection of liver metastases were 86%, 81%, 97%, 47%, and 85% and 50%, 100%, 100%, 22%, and 56%, for FDGPET/ MRI. FDG-PET/MRI was significantly less accurate than MRI alone (p .001). Conclusion: In opposite to patients before systemic anticancer therapy the fusion of FDG-PET data with liver MRI cannot be recommended for the detection of liver metastases in patients undergoing systemic oncological therapy.
Keywords :
PET , MRI , PET , CT , liver MRI , liver metastases , hybrid imaging.
Journal title :
International Journal of Radiation Research
Journal title :
International Journal of Radiation Research
