effect of endurance training with royal jelly on crp gene expression in muscle tissue of rats with alzheimer ’s disease

background: studies have shown that alzheimer’s disease (ad) causes neuromuscular dysfunction by damaging different parts of the central nervous system and inflammation that can increase c-reactive protein (crp) levels. nevertheless, the beneficial effects of endurance training (et) and royal jelly (rj) on inflammation and reduction of crp are not fully elucidated. objectives: the aim of this research was to investigate the effect of et with rj on gene expression of crp in muscle tissues of rats with ad. methods: in this experimental study, 24 rats with ad (8 mg/kg trimethyltin injection) were randomly divided into four groups of 1-et, 2-et + [rj (100 mg/kg)], 3-rj and 4-control. also, six healthy rats were placed in the healthy control group to investigate the effects of ad induction on crp gene expression. endurance training groups performed endurance training with a speed of 15 - 20 m/min, 5 sessions per week for eight weeks. results: our findings showed et and rj significantly decreased crp gene expression in muscle tissues of rats with ad (p = 0.001) as well as the interaction of et and rj was significant in reducing crp gene expression in muscle tissues of rats with ad (p = 0.001). conclusions: it appears that et and rj have interactive effects on the reduction of crp in muscle tissues of rats with ad.