Title of article :
Psychosis, Mood and Behavioral Disorders in Usher Syndrome: Review of the Literature
Author/Authors :
Domanico, Daniela Sapienza University of Rome - U O S D Ophthalmology - Department of Medical–Surgical Sciences and Biotechnologies, Italy , Fragiotta, Serena Sapienza University of Rome - U O S D Ophthalmology - Department of Medical–Surgical Sciences and Biotechnologies, Italy , Cutini, Alessandro Sapienza University of Rome - U O S D Ophthalmology - Department of Medical–Surgical Sciences and Biotechnologies, Italy , Grenga, Pier Luigi Sapienza University of Rome - U O S D Ophthalmology - Department of Medical–Surgical Sciences and Biotechnologies, Italy , Vingolo, Enzo Maria Sapienza University of Rome - U O S D Ophthalmology - Department of Medical–Surgical Sciences and Biotechnologies, Italy
Abstract :
The aim of this review is to focus the current knowledge about mental and behavioral disorders in Usher syndrome. Previous studies described the presence of various mental disorders associated with Usher syndrome, suggesting possible mechanisms of association between these disorders. The most common manifestations are schizophrenia-like disorder and psychotic symptoms. Mood and behavioral disorders are rarely described, and often are associated with more complex cases in co-occurrence with other psychiatric disorders. Neuroimaging studies reported diffuse involvement of central nervous system (CNS) in Usher patients, suggesting a possible role of CNS damage in the pathogenesis of psychiatric manifestations. Genetic hypothesis and stress-related theories have also been proposed.
Keywords :
Usher Syndrome , Retinitis Pigmentosa , Schizophrenia , Psychosis , Hearing Loss
Journal title :
Medical Hypothesis, Discovery & Innovation Ophthalmology
Journal title :
Medical Hypothesis, Discovery & Innovation Ophthalmology
