Author/Authors :
Faryal, Uzma Women Medical College - Department of Biochemistry, Pakistan , Faryal, Uzma CMH, Pakistan , Rashid, Shazia Women Medical College - Department of Biochemistry, Pakistan , Rashid, Shazia CMH, Pakistan , Hajra, Bibi Women Medical College - Department of Biochemistry, Pakistan , Hajra, Bibi CMH, Pakistan
Abstract :
Background: All available contraception methods have both advantages and disadvantages and it is up to the health provider to make a rational choice. The purpose of this study was to determine the effect of combined oral contraceptive pills on lipid profile in females of reproductive age group. Material Methods: This comparative cross-sectional study was conducted at Lahore General Hospital, Lahore. A total of 250 married fertile women in their reproductive age were selected. They were divided in two groups: Group 1 (controls) and Group 2 (combined oral contraceptive users at least for one year). Lipid profile was measured using standard kits. Low density lipoprotein-cholesterol was calculated with Fried Wald equation. Results were analyzed by using student’s t test. Results: The mean age of the patients in group 1 was 30.8±6.5 and group 2 was 30.8±6.2 years. For subjects in group 1 and group 2 the mean concentration of serum total cholesterol was 177.9±40.8 and 194.1±53.0mg/ dl, respectively. It was significantly increased in group 2 as compared to group 1 (p=0.01). The serum triglycerides were 129.1±27.7 and 153.5±28.3mg/dl, respectively, highly significantly increased in group 2 as compared to group 1 (p 0.001). Serum HDL-C was 53.1±7.6 and 52.8±8.3mg/dl in the two groups respectively. It was insignificantly decreased in group 2 (p=0.8). Serum LDL-C was 130.0±14.9 and 123.1±14.6.0mg/dl, respectively. This difference was highly significantly (p 0.001). Conclusion: Combined oral contraceptive pills adversely affect the lipid profile in females of child bearing age
