Author/Authors :
Farooqi, Javed Iqbal Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan , Farooqi, Rukhsana Javed Khyber Teaching Hospital, Pakistan , Khan, Nowshad Gomal Medical College - Department of Medicine, Pakistan , Muhammad, Riaz Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan , Khan, Noorullah Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan , Rehman, Abdur Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan , Ali, Zafar Lady Reading Hospital - Post Graduate Medical Institute(PGMI) - Department of Medicine, Pakistan , Alam, Intekhab Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan , Khan, Mohammad Jamshed Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan , Asghar, Muhammad Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan , Ahmad, Farooq Lady Reading Hospital - Post Graduate Medical Institute (PGMI) - Department of Medicine, Pakistan
Abstract :
Background: Genetic variation in the interleukin 28B (IL28B) gene has been associated with response to Interferon- α Ribavirin (IFN+Riba) therapy in hepatitis C virus (HCV) genotype 1-infected patients; there is limited data for HCV patients with genotype 3. We evaluated the effects of IL28B polymorphisms on response to treatment with IFN+Riba in patients with HCV genotype 3. Material Methods: This cross-sectional study was conducted in Medical A Ward, PGMI, Lady Reading Hospital and Author’s Private Hepatology Clinic, Peshawar, Pakistan from July 2013 to June 2014. IL28B host genotypes (CC, CT and TT) were analyzed in 184 patients of chronic hepatitis C genotype 3, for association with outcome of antiviral therapy with IFN+Riba, using SPSS version 16.0. Results: The frequencies of the IL28B genotypes were as follows: CC, 24.5%; CT, 60.3%; and TT, 15.2%; Non-CC genotype was significantly associated with the Non-Responder status of the studied patients of HCV genotype 3 irrespective of their gender and genotype subtype status, with statistically sagnifiant association between virological and clinical profile (p=0.001). Conclusion: An IL28B polymorphism (Non-CC genotype) was associated with Virological non-Response in patients infected with genotype 3 HCV who did not achieve a RVR. Analysis of IL28B genotype might be used to guide treatment for these patients
Keywords :
IL28B polymorphism , Hepatitis C virus , Genotype 3 , Sustained virological response
