Title of article :
Metronomic Maintenance Therapy in Refractory Acute Myeloblastic Leukemia with Monosomy 7
Author/Authors :
Shahriari, Mahdi shiraz university of medical sciences - Amir Oncology Hospital - Department of Pediatrics, ايران , Abdolkarimi, Babak lorestan university of medical sciences - Department of Pediatrics, ايران , Saleh, Fazl shiraz university of medical sciences - Amir Oncology Hospital - Department of Pediatrics, ايران , Salajeghe, Pooria iran university of medical sciences - Aliasghar Hospital - Department of Pediatrics, ايران
Abstract :
Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we report a patient with primary refractory AML who was treated with oral low-dose chemotherapy after standard systemic chemotherapy.
Keywords :
Metronomic Chemotherapy , Histone deacetylase Inhibitor , Acute Myeloblastic Leukemia , Valporic acid , All , trans retinoic acid
Journal title :
Iranian Journal of Blood and Cancer (IJBC)
Journal title :
Iranian Journal of Blood and Cancer (IJBC)
