Title of article :
INDONESIAN HERBALS REDUCE CHOLESTEROL LEVELS IN DIET-INDUCED HYPERCHOLESTEROLEMIA THROUGH LIPASE INHIBITION
Author/Authors :
SARI, IKA PUSPITA Gadjah Mada University - Faculty of Pharmacy - Department of Pharmacology and Clinical Pharmacy, Indonesia , NURROCHMAD, ARIEF Gadjah Mada University - Faculty of Pharmacy - Department of Pharmacology and Clinical Pharmacy, Indonesia , SETIAWAN, IRFAN MURIS Gadjah Mada University - Faculty of Pharmacy - Department of Pharmacology and Clinical Pharmacy, Indonesia
Abstract :
Water and ethanolic extracts of Guazuma, Gynura, Muraya and Roselle were evaluated for their antihypercholesterolaemia and antilipase activities in high fat diet (HFD)-induced rats. Ethanolic and water extracts were given on days 31–45. Total cholesterol and lipase activity in serum were measured. Guazuma water(Guw) and ethanolic (GuEt) extracts, Gynura water (Gyw) extract, Muraya ethanolic (MEt) extract as well as Roselle water (Rw) and ethanolic (REt) extracts caused reduction in cholesterol levels of HFD-induced rats significantly (17%–23%; p 0.05). The potency of GuEt extract and Rw extract were similar to that of orlistat. Gyw extract, MEt extract and Rw extract reduced dietary fat absorption by inhibiting lipase activity.
Keywords :
Guazuma , Gynura , Muraya , Roselle , Lipase activity
Journal title :
Malaysian Journal of Pharmaceutical Sciences
Journal title :
Malaysian Journal of Pharmaceutical Sciences
