Title of article
Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats
Author/Authors
SHARIF, FAEZ International Islamic University Malaysia - Kulliyah of Science - Department of Biotechnology, Malaysia , HAMID, MUHAJIR Universiti Putra Malaysia - Faculty of Biotechnology and Biomolecular Sciences - Department of Microbiology, Malaysia , ISMAIL, AMIN Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Nutrition and Dietetics, Malaysia , ADAM, ZAINAH Malaysian Nuclear Agency - Medical Technology Division, Malaysia
From page
37
To page
43
Abstract
Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats
Keywords
Elaeis guineensis , oil palm fruit extract , blood glucose level , hypoglycaemic , antihyperglycemic
Journal title
Malaysian Journal of Health Sciences
Journal title
Malaysian Journal of Health Sciences
Record number
2571614
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