Title of article :
Vitiligo: new etiology-based treatments
Author/Authors :
Hameed, Abdul King Edward Medical College - Mayo Hospital - Department of Dermatology Unit-I, Pakistan , Rani, Zahida Mayo Hospital - King Edward Medical College - Dermatology Department, Unit I, Pakistan , Kazmi, Atif Hasnain Mayo Hospital - King Edward Medical College - Department of Dermatology, Pakistan
Abstract :
Vitiligo is an acquired depigmentary disorder characterized by a chronic and progressive loss of melanocytes from the epidermis. The etiopathogenesis of vitiligo is still not fully understood, and the major theories include melanocyte destruction (autoimmune, neural and impaired redox status) and melanocyte inhibition or defective adhesion. Recently a new theory, melanocytorrhagy, was forwarded. In this review are also discussed the new etiology- based treatments, mainly topical calcipotriol, topical immunomodulators and topical catalase.
Keywords :
vitiligo , calcipotriol , tacrolimus , pimecrolimus , catalase.
Journal title :
Journal of Pakistan Association of Dermatologists
Journal title :
Journal of Pakistan Association of Dermatologists
