Author/Authors :
Nepali, Narayan Dhulikhel Hospital - Department of Pediatrics, Nepal , Alam, Kadir Kathmandu University - Department of Pharmacy, Nepal , Khan, G. M. Kathmandu University - Department of Pharmacy, Nepal , Shrestha, RPB Dhulikhel Hospital - Department of Pediatrics, Nepal , Subish, P. Manipal College of Medical Sciences - Manipal Teaching Hospital - Department of Hospital and Clinical Pharmacy/ Pharmacology, Nepal , Mishra, Pranaya Manipal College of Medical Sciences - Manipal Teaching Hospital - Department of Hospital and Clinical Pharmacy/ Pharmacology, Nepal , Koju, Rajendra Dhulikhel Hospital - Department of Cardiology, Nepal
Abstract :
Phenobarbitone is an antiepileptic known to cause skin reactions in 1 to 3% of patients. Wereport a case of erythema multiforme-macular type skin reaction in an 8-year-old femalechild that occurred immediately following administration of single dose phenobarbitone.The patient presented with confluent erythema with edema on both legs, dorsum of handsand face. The patient was treated symptomatically and given tab. prednisolone. The causalrelationship between the drug was ‘probable’ and the severity ‘moderate [level 4(b)] andthe preventability to be ‘not preventable’.
