Author/Authors :
JESMIN, M. University of Rajshahi - Department of Applied Chemistry and Chemical Technology, Bangldesh , ALI, M.M. University of Rajshahi - Department of Applied Chemistry and Chemical Technology, Bangldesh , BISWAS, A. K. University of Rajshahi - Department of Applied Chemistry and Chemical Technology, Bangldesh , HABIB, M. R. University of Rajshahi - Department of Biochemistry and Molecular Biology, Bangldesh , KHANAM, J. A. University of Rajshahi - Department of Biochemistry and Molecular Biology, Bangldesh
Abstract :
Ni(II)-cystine complex was synthesized by treating saturated aqueous solutions of Ni (II) acetate and L(-) cystine (in 1: 1 molar ratio). The complex was used to study its antineoplastic activity against EAC cells in Swiss Albino mice. It was found that the Ni (II) complex restored the depleted haematological and biochemical parameters of the EAC bearing mice towards normal values and enhanced the longevity of such mice significantly. The test compound on the other hand showed negligible host toxicity. The results obtained were compared with those obtained with a standard anticancer drug bleomycin.
