Title of article
Independent Regulation of Na+ and K+ Balance by the Kidney
Author/Authors
Castañeda-Bueno, María Universidad Nacional Autónoma de México - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas - Molecular Physiology Unit, Mexico , Arroyo, Juan Pablo Universidad Nacional Autónoma de México - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas - Molecular Physiology Unit, Mexico , Gamba, Gerardo Universidad Nacional Autónoma de México - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas - Molecular Physiology Unit, Mexico
From page
101
To page
114
Abstract
The understanding of the independent regulation of sodium and potassium by the kidney has remained elusive. Recent evidence now points to dissimilar regulatory mechanisms in ion handling, dependent on the presence of either aldosterone alone or angiotensin II with aldosterone among other factors. This review summarizes past and present information in an attempt to reconcile the current concepts of differential regulation of sodium and potassium balance through the with-no-lysine (K) kinase (WNK) system and the previous knowledge regarding ion transport mechanisms in the distal nephron.
Keywords
Angiotensin II , Aldosterone , Sodium balance , Potassium balance , Na+ , Cl , cotransporter , Renal outer medullary K+ channel , Apical Na+ channel , WNK kinases
Journal title
Medical Principles and Practice
Journal title
Medical Principles and Practice
Record number
2575569
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