Coronary Artery Bypass Grafting In Familial Hypercholesterolemia

Objectives: Familial hypercholesterolemia is dominantly inherited disorder caused mutation by at the locus for the low-density lipoprotein receptor and is frequently associated with premature coronary artery disease. This study was performed to determine outcomes of coronary artery bypass grafting for patients with familial hypercholesterolemia.Methods: During the past 7 years, 11 from 12 patients with heterozygous familial hypercholesterolemia underwent primary coronary artery bypass grafting and 1 from 12 patients underwent PCI without hospital death. All patients received one internal thoracic artery graft and supplemental vein grafts. After operation all patients received diet therapy and intensive cholesterol-lowering therapy. 4 patients received low density lipoprotein aphaeresis.Results: Both groups were similar regarding During follow up period (range 1 to 84 months, mean 16 months) there was no cardiac death but 2 of them had recurrent disease. Inspite of severe coronary atherosclerosis, these patients with familial hypercholesterolemia showed good short term outcomes after coronary artery bypass surgery.Conclusion: The present finding suggests that aggressive use of arterial and venous grafts, intensive cholesterol-lowering therapy and low-density lipoprotein aphaeresis may be useful in patients with familial hypercholesterolemia