Author/Authors :
Habib, Ahmed A. Department of Pharmaceutical Analytical Chemistry - Faculty of Pharmacy - University of Tanta - El Geish St - Tanta - El gharbeya, Egypt , M. Hendawy, Hassan A. National Organization for Drug Control and Research (NODCAR) - 6 Abu Hazem Street - Pyramids Ave - P.O. 29, Cairo, Egypt , Hammad, Sherin F. Department of Pharmaceutical Analytical Chemistry - Faculty of Pharmacy - University of Tanta - El Geish St - Tanta - El gharbeya, Egypt , Bebawy, Lories I. National Organization for Drug Control and Research (NODCAR) - 6 Abu Hazem Street - Pyramids Ave - P.O. 29, Cairo, Egypt , Girges, Marian A. National Organization for Drug Control and Research (NODCAR) - 6 Abu Hazem Street - Pyramids Ave - P.O. 29, Cairo, Egypt
Abstract :
The electrochemical behavior of tetrahydrozoline (THZ) was explored by cyclic voltammetry and differential pulse voltammetry. A well-defined peak at 915 mV using gold nanomodified electrode (AuNPts/CP) in presence of sodium dodecyl sulphate (SDS) was detected. Different buffers, pH and scan rates on oxidation peak current were studied. Linear calibration curve was achieved in the range of 1.99×10−5 to 7.79×10-5 M with a limit of detection (LOD) 5.54×10-6 M and limit of quantification (LOQ) 1.69×10−5 M, respectively. The suggested method was successfully utilized to the eye drops dosage form and urine sample with percentage recovery, 98.86%±0.77, and 101.13±0.62, respectively.
Keywords :
Tetrahydrozoline , Voltammetry , Gold nanoparticles , Carbon paste , Surfactant , electroanalysis
