Polycystic ovarian syndrome: Response to metformin therapy

Objective: To determine the response of polycystic ovarian syndrome (PCOS) to metformin therapy. Methodology: This study was conducted from January 2006 to December 2007 at Peoples Medical College Hospital Nawabshah. All the patients presenting with infertility, menstrual irregularity and increase body mass index (BMI) were included. Diagnosis was confirmed by clinical presentation and ultrasound finding. Patients diagnosed with PCOS were given metformin for six months, the clomiphene was added for three months if the patients did not conceive. Later metformin alone was continued and patients were re-evaluated after one year. Result: Total 63 patients, mean age of PCO was 24.49 ± 4.87 years and married were 52 (82.53%) cases, 44 (69.83%) cases were present with menstrual irregularity, 31–74% were overweight, 6.34% obese. 52 cases with infertility in which 39 (74.98%) cases had conceived. Conclusion: Metformin significantly increase ovulation and conception rate.