Title of article
Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms
Author/Authors
Tabrizi، Arash Rafii نويسنده , , McGrath، Sean D. نويسنده , , Blinder، Morey A. نويسنده , , Buchman، Timothy G. نويسنده , , Zehnbauer، Barbara A. نويسنده , , Freeman، Bradley D. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
-143
From page
144
To page
0
Abstract
Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.
Keywords
neutropenic enterocolitis , typhlitis , acute leukemia
Journal title
American Journal of Hematology
Serial Year
2001
Journal title
American Journal of Hematology
Record number
25769
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