Title of article
Morinda citrifolia extract inhibits proliferation of non-small human lung cancer cell line NCI-H23 via apoptosis by modulating the Bax:Bcl-2 ratio
Author/Authors
Kharis, Z. Malaysian Agricultural Research and Development Institute Headquarters - Food Technology Research Centre, Malaysia , Azimahtol Hawariah, L.P. Universiti Kebangsaan Malaysia - Faculty of Science Technology - School of Biosciences Biotechnology, Malaysia , Normah, A. Malaysian Agricultural Research and Development Institute Headquarters - Food Technology Research Centre, Malaysia , Aishah, R. MARDI Headquarters - Food Technology Research Centre, Malaysia
From page
203
To page
209
Abstract
The involvement of Bcl-2 gene family in cells apoptosis mechanism is well described in many studies against cell death after treatment with anticancer drugs. Previously, the potential of M. citrifolia extract to inhibit proliferation and induce apoptosis in human lung adenocarcinoma cell growth was carried out. The mechanism involved in apoptosis of NCI-H23 cells after treated with M. citrifolia extract was studied. A search for the molecular mechanism revealed that M. citrifolia extract burden decrease the expression of the pro-apoptotic protein Bcl-2 but the level of Bax protein remain. These in consequence elevated the ratio of Bax:Bcl-2 in apoptotic cell. These findings indicated that the apoptotic events by M. citrifolia extract were associated with down-regulation of Bcl-2 protein expression in NCI-H23 cells.
Keywords
Morinda citrifolia , lung cancer , apoptosis , Bax , Bcl , 2
Journal title
Journal of Tropical Agriculture and Food Science
Journal title
Journal of Tropical Agriculture and Food Science
Record number
2576949
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