Author/Authors :
Jiang, Kailun University of Ottawa - Ottawa Hospital, Ottawa Hospital Research Institute - Department of Ophthalmology, Department of Pathology and Laboratory Medicine, Canada , Brownstein, Seymour University of Ottawa - Ottawa Hospital, Ottawa Hospital Research Institute - Department of Ophthalmology, Department of Pathology and Laboratory Medicine, Canada , Sekhon, Harmanjatinder S. University of Ottawa - Ottawa Hospital, Ottawa Hospital Research Institute - Department of Pathology and Laboratory Medicine, Canada , Laurie, Scott A. University of Ottawa - Ottawa Hospital, Ottawa Hospital Research Institute - Department of Medical Oncology, Canada , Lam, Kay University of Ottawa - Ottawa Hospital, Ottawa Hospital Research Institute - Department of Ophthalmology, Department of Pathology and Laboratory Medicine, Canada , Gilberg, Steven University of Ottawa - Ottawa Hospital, Ottawa Hospital Research Institute - Department of Ophthalmology, Canada , Britton, William University of Ottawa - Ottawa Hospital, Ottawa Hospital Research Institute - Department of Ophthalmology, Canada
Abstract :
Choroidal metastasis is the most common intraocular neoplasm and is associated with significant morbidity. In a small percentage of patients, ocular manifestation may be the initial presentation of a systemic malignancy and can be diagnostically difficult to distinguish from ocular primary malignancies. Herein, we present a case of a never-smoker whose ocular pathology was integral to thediagnosis and management of a lung adenocarcinoma harboring a rare oncogene. Through this case, we have explored important diagnostic and therapeutic considerations of pulmonary metastases to the choroid.
Keywords :
Choroidal metastasis , Non , small cell lung carcinoma , Adenocarcinoma , EML4 , ALK translocation , Targeted therapy , Crizotinib
