Title of article :
FOURNIER S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME
Author/Authors :
El Awady, Saleh Mansoura University Hospital - Surgery Dept, Egypt , Khafagy, Wael Mansoura University Hospital - Surgery Dept, Egypt , Abd El-Raof, Mohamed Mansoura University Hospital - Mansoura General Hospital, Egypt , Ragab, Elham Mansoura University Hospital - Clinical Pathology Dept, Egypt , Fareed, Mohamed Mansoura University Hospital - Surgery Dept, Egypt
Abstract :
Aim: Identify Fournier s disease associations, outcome and survival factors. Methods: Fournier s gangrene patients (34) were treated between 2003 to 2006. Data were collected about medical history, physical findings, metabolic tests, bacteriologic typing, immunologic screening for T cell function, serum IL-2, ICAM-I and γlFN with their management. Results: The disease had age range 3 - 67 years, polymicrobial nature, and loiv serum albumin (3.3 ±0.6 mg/dl). Inadequate Tcell function (18255.3 ± 1641 CPM) and high ICAM-I, IL-2, γlFN (10.5 ± 0.7, 93.3 ± 1.6, 131 ± 2 pg/ml) zvere detected in Fournier s disease but serum IL-2 ivas relevant to outcome (P = 0.0001). Tlie survival factors zvere patients age (P = 0.0001), presentation timing (P = 0.001), both disease extent (P = 0.0001),septic shock(P = 0.01),severe SIRS (P = 0.001), serum albumin(P = 0.0001) and IL-2. Conclusion: Fournier s disease is consistent with deviated metabolic status and immunologic dissonance, inciting local gangrenous process, these parameters are significant for disease outcome
Keywords :
Necrotizing fasciitis , immunologic dissonance , SIRS
Journal title :
The Egyptian Journal of Surgery
Journal title :
The Egyptian Journal of Surgery
