Author/Authors :
Honarmand, H. guilan university of medical sciences - Cellular and Molecular Research Center, رشت, ايران , Eshraghi, S. tehran university of medical sciences tums - School of Public Health and Institute of Public Health Research - Dept of Pathobiology, تهران, ايران , Khorramizadeh, M. R. tehran university of medical sciences tums - School of Public Health and Institute of Public Health Research - Dept of Pathobiology, تهران, ايران , Hartskeerl, R. A. WHO/FAD Collaboration Center - reference laboratory in leptospirosis, The Netherlands , Ghanaei, F. M. guilan university of medical sciences - Gastrointestinal and Liver Diseases Research Center, رشت, ايران , Abdolahpour, G. R. university of tehran - Dept of Microbiology, تهران, ايران , Eshraghian, M. R. tehran university of medical sciences tums - School of Public Health and Institute of Public Health Research - Dept of Pathobiology, تهران, ايران
Abstract :
Background: Leptospirosis is the most widespread zoonosis in the world and is more prevalent in tropic al and temperate regions. Guilan Province in north of Iran, is an endemic region of human leptospirosis. Since diagnosis of leptospirosis according to clinical symptoms is very diffi cult due to lack of characteristic pathogonomic sign (s), laboratory support is necess ary . Methods: In 2003, we obtained blood samples from patients hospitalized in main general hospitals of Guilan Province and were suspected as having leptospirosis according to their clinical presentations. We examined 995 sera by a commercial IgM and IgG ELISA kit to find positive cases . Results: 62.7% of pos itive cases were male and about 86% of them were farmer. High distr ibution rate of leptospirosis was seen in middle-aged people (65% in 20-50 years old). Conclusion:It seems that leptospirosis has a high occurrence in major cities and is mostly distributed in warm months of the year. Demographic anal ysis of the results indicates that leptospiro sis is typicall y a rural and an occupational disease in the area.
Keywords :
Leptospirosis , Zoonosis , ELISA , Iran
