Title of article
Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast
Author/Authors
Goverdhan, Gilla Dr. Reddy’s Laboratories Ltd, India , Reddy, Anumula Raghupathi Dr. Reddy’s Laboratories Ltd, India , Himabindu, Vurimidi Jawaharlal Nehru Technological University - Institute of Science and Technology, Center for Environmental Science, India , Reddy, Ghanta Mahesh Macleods Pharmaceuticals Limited, India
From page
129
To page
138
Abstract
Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent. Synthesis and characterization of these impurities and investigation of the root cause of their formation is described.
Keywords
Zafirlukast , Asthma drug , Process impurities , Leukotriene
Journal title
Journal of Saudi Chemical Society
Journal title
Journal of Saudi Chemical Society
Record number
2580451
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