Toxicopathological Changes in Internal Organs of Albino Mice after Treatment with Sumithrin

The objective of the present study was to evaluate the toxic effect of sumithrin on the histological state of internal organ and body weight change of mice. Forty adult Swiss Albino mice at the age of two months were divided into four groups. The1st group(G1) was administrated orally with ( 60 mg / kg b.w) of sumithrin daily for 6 weeks, 2nd group(G2) was administrated sumithrin as G1 group and at the same time fed on pellet contains (200 mg/ kg pellet) of beta-glucan for 6 weeks. 3rd group (G3)was fed with beta-glucan as 2nd group. 4rd group (G4) was considered as control negative.At end of the experiments (6 weeks), all animals were sacrificed and Specimens were taken from internal organs like liver, kidney, spleen, heart and brain. The tissues were kept in 10% formaldehyde solution, for fixation, and then processed routinely by using the histokinete. Tissue sections were embedded in paraffin blocks, and sectioned by microtome and stained with hematoxylin and eosin stain, then examined by using light microscope. The pathological lesions showed that the animals exposed to toxic dose of sumithrin was characterized by inflammatory reaction, hemorrhage, congested blood vessels, necrosis, fibrosis and multiple granuloma lesions in internal organs and proliferation Astrocyte and gliosis in the brain while less lesions were recorded in the groups treated with beta-glucan showed improvement against toxic effect of sumithrin. As well as sumithrin causes dacrease body weight.